Eicosanoids are lipid products derived from the metabolism of AA,
which play a significant role as mediators of the inflammatory cascade
and have important activities for maintaining homeostasis [37]. AA is
a ω-6-PUFA and is the primary source of fatty acids that mediate
inflammatory responses [9]. Elevated tissue levels of AA have been
associated with a number of disease states, including coronary heart
disease, breast cancer, obesity and diabetes [38]. A recent study has
associated increased AA levels in retroperitoneal AT with a high
prevalence of the metabolic syndrome in human subjects [38]. We
found that cocoa-supplemented mice had 33% lower levels of AA
compared to HF group, furthermore.