The tomato SlERF1 gene belongs to a distinct subfamily of the large ERF gene family. It is a downstream component in the ethylene signaling pathway in tomato, and is involved in plant defense and stressresponses. Overexpression of the SlERF1 gene (SlERF1-OEs) in tomato dramatically enhanced the resis-tance of fruit to Rhizopus nigricans. In attempt to elucidate the mechanism basis of this observation, ourstudy revealed a dual modulation. Firstly, SlERF1-OEs fruit showed a remarkable transcript accumulationof PR5 and PAL genes before infection with R. nigricans, which was not observed in wild-type (WT) fruit.Secondly, SlERF1-OEs fruit had higher activitiers of phenylalanine ammonia lyase (PAL) and chitinase(CHI) in response to the fungal stress. These results show that SlERF1 positively modulated the ethylene-dependent pathogenesis defense pathway in tomato. That may be one of the mechanisms by which ERFsenhance plant tolerance to fungal invasion.