A
complex process of cellular injury underlies such irregularities
with banking and often manifests asRBChemolysis
within the unit, thus promoting increases in supernatant
potassium and free hemoglobin (Hb) concentrations.1
In addition, RBC-derived microparticles are formed as
a result of storage-induced blebbing, shedding, and
fragmentation.2Exposureof patients toplasmafreeHband
RBCmicroparticlesmaycontribute to adverse events associated
with transfusion.2-6 For example, plasma free Hb
concentrations in septic patients were reported to be an
independent predictor of mortality.7
There is growing enthusiasm for the prospect of
improving stored RBC quality and removing injurious
by-products of RBC storage by washing units before
transfusion.8-10 In a recent prospective clinical trial,
Acomplex process of cellular injury underlies such irregularitieswith banking and often manifests asRBChemolysiswithin the unit, thus promoting increases in supernatantpotassium and free hemoglobin (Hb) concentrations.1In addition, RBC-derived microparticles are formed asa result of storage-induced blebbing, shedding, andfragmentation.2Exposureof patients toplasmafreeHbandRBCmicroparticlesmaycontribute to adverse events associatedwith transfusion.2-6 For example, plasma free Hbconcentrations in septic patients were reported to be anindependent predictor of mortality.7There is growing enthusiasm for the prospect ofimproving stored RBC quality and removing injuriousby-products of RBC storage by washing units beforetransfusion.8-10 In a recent prospective clinical trial,
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