The first aim of the present study was to test in a randomized controlled trial whether participation
in this structured weight loss program promotes greater 1-year weight loss and maintenance in
overweight or obese adults with type 2 diabetes compared with UC conditions. A secondary aim
was to describe the effect of participating in the program (vs. UC) on markers of glycemic control
(fasting glucose, hemoglobin A1c [HbA1c]), cardiovascular disease risk factors (triglyceride,
HDL cholesterol, C-reactive protein [CRP] levels), cardiopulmonary fitness, quality of life, and plasma carotenoids (a biomarker of vegetable and fruit intake). An exploratory aim was to examine
whether there is a differential response to dietarymacronutrient composition (higher vs. lower carbohydrate) in weight change and markers of glycemic control and cardiovascular disease risk.