May be increased to 20 mg. Max (for all indications): 20 mg/day. Elderly = 65 yr initially 1 the usual recommended dose. Consider lower max dose. Severely reduced renal function (CrCl 30 mL/min) Adjust dose. Reduced hepatic function/poor CYP2C19 metabolisers initially 2 mg daily for the 1st 2 wk. Max: 10 mg daily.