A potential other explanation is that statins do reduce coagulation, which was suggested by Sahebkar et al. because D-dimer levels decreased after 3 months of statin therapy and because D-dimer levels are markers of coagulation [14]. To get more insight whether simvastatin and rosuvastatin have anticoagulant properties, a next step would be to investigate the effect of these statins on coagulation in patients not on VKAs.