The authors thank Bruno M. Fonseca and Isabel Pacheco for
helpful discussions during the performance of this work and
Ryan A. Melnyk for help with preparation of genomic DNA and
early expression trials. This work was supported by Fundação da
Ciência e Tecnologia (FCT) Portugal [Grants SFRH/BD/88664/2012
to Nazua Costa and SFRH/BPD/96952/2013 to Catarina Paquete].
The NMR spectrometers are part of The National NMR Facility, supported
by Fundação para a Ciência e a Tecnologia (RECI/BBB-BQB/
0230/2012). Mass spectrometry data were obtained by the Mass