This increase was significantly reduced by pretreatment with the MeOH extract and the CH2Cl2 soluble fraction of the E. bicyclis at a concentration of 50 lg/mL by 38.5% and 41.2%, respectively, as compared with that of the positive control, AMT (89.33% inhibition at 10 lM). However, the EtOAc, n-BuOH, and H2O fractions did not inhibit NO production in the LPS-induced cells at the same concentration