The restraining functions are made from the distances as described by Kim et al. [21] (Figure 1b)—quadratic functions are drawn with their minima on the internuclear distance points from templates, the lowest-lying values on each spline point are taken, and then clamped cubic spline interpolation makes a restraint for an atom pair. In order to avoid redundancy with NOE-restraints, we use only those from atom pairs separated by more than five residues in amino acid sequence, which are abbreviated as RDS (Residues Distant in Sequence)’s in the following