Recommended agents for the prevention and management of bone loss include zoledronate
(IV 4 mg over no less than 15 min every 6–12 months) and denosumab (60 mg SC every 6 months). Any oral bisphosphonate is acceptable as well, including clodronate (1600 mg per day), risedronate(35 mg per day), or alendronate (70 mg per day). The route of administration should be left to the discretion of the treating physician, taking into account compliance with treatment, cost of treatment,and patient preference.