The major difference between all natural toothpastes and conventional toothpastes such as Colgate Total® Clean Mint is the ingredients they contain. Although no toothpastes contain sugar – which contributes to tooth decay – conventional products do contain some type of sweetener to improve their taste, such as saccharin. It's significantly sweeter than regular sugar, and its health effects, so Colgate has always been open for debate so naturally, some people prefer to avoid it. All natural toothpastes also have sweeteners, but these ingredients, such as xylitol and stevia, come from herbs.