Incidence
The incidence of leukopenia (white blood cells < 5000/ mm3) in AIDS patients ranges from 57% to 76%; leuko-penia affects 19% to 41% of HIV-infected patients with lymphadenopathy. Leukopenia may also occur in the setting of acute HIV infection.44 Up to 44% of PWAs have granulocytopenia.8 As the CD4 count falls below 100 cells/mm3, the risk for developing granulocytopenia is increased. The Multicenter AIDS Cohort Study found that significantly fewer patients with CD4 counts greater than 700 cells/mm3 had low granulocyte counts (0.8%), compared with 13.4% of those with CD4 counts below 249 cells/mm3.