Rats were divided in 5 groups of 10 animals each and anesthesia was administered by an intramuscular injection of xylazine 10mgkg-1 and ketamine 75mgkg-1. The right side skin of the rats was shaved and the underlying skin cleaned with 70% ethanol. An incision of 4cm on the shaved skin was made and sutured. Sutures were made with Nylon 0 thread with cutting needle. Sutures were simple and were made at the ends and in the middle of the wound. Group I-IV was treated with 0.2 sesame oil extract, 0.13 sesame oil extract, 0.1 sesame oil extract and standard treatment (Gentamycin ointment (1 %)) respectively. Group V was treated with olive oil as the control group. All of the extracts and the ointment and olive oil were used topically so the whole wounds were soaked and covered with the substance. The rats were treated with the substances once a daily until epithelialization and complete wound closure was recorded. Wounds were left undressed to the open environment and the animals were kept individually in separate cages. The progressive changes in wound length were measured in centimeter at every 3 days interval until epithelialization and complete wound closure was recorded. Wound contraction was calculated as a percentage of the original wound size. Progressive decrease in the wound size was monitored periodically. The relative wound area results were compared using one- way analysis of variance (ANOVA) followed by Dunnett’s tests. P values less than 0.05 were considered as indicative of significance.