Previously, we identified a putative serine protease inhibitor
(SRPN6) that modulates rodent malaria parasite development in
anopheline mosquitoes [19,20]. In An. stephensi, SRPN6-silencing
leads to a significant increase in P. berghei oocyst numbers [19].
However, in a susceptible line of An. gambiae (G3), SRPN6-
silencing has no effect on the number of developing parasites [19].
Further experiments would suggest that AgSRPN6 mediates
parasite recognition and/or lysis and may additionally be involved
in the regulation of the melanization response [19,21], yet the
precise function of SRPN6 in the mosquito immune response is
still unknown.
Previously, we identified a putative serine protease inhibitor(SRPN6) that modulates rodent malaria parasite development inanopheline mosquitoes [19,20]. In An. stephensi, SRPN6-silencingleads to a significant increase in P. berghei oocyst numbers [19].However, in a susceptible line of An. gambiae (G3), SRPN6-silencing has no effect on the number of developing parasites [19].Further experiments would suggest that AgSRPN6 mediatesparasite recognition and/or lysis and may additionally be involvedin the regulation of the melanization response [19,21], yet theprecise function of SRPN6 in the mosquito immune response isstill unknown.
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