for overall survival in both groups can be seen in Figure 4The overall survival of the SiNE group was significantly higher than in the control group, with a mean survival time of 16.86 monthsIn the control group, a mean survival time of 5.3 months was obtained One year after the treat ment, 60% of the patients of the SiNE group vs. 10% of the control group remained alive, and after the 32 months follow-up, the survival rate for the SiNE group is 30% vs. 0% for the control group.