The Nottingham Health Profile is frequently
used in patients with pituitary disease to assess general wellbeing
and consists of 38 yes/no questions, which are subdivided into six
scales assessing impairments, i.e. pain (eight items), energy level (three
items), sleep (five items), emotional reactions (nine items), social isolation
(five items), and disability/functioning, i.e. physical mobility (eight
items) (11, 12). Subscale scores are calculated as a weighted mean of the
associated items and are expressed as a value between 0 and 100. The
total score is the mean of the six subscales. A higher score is associated
with a worse quality of life. Age-related west European reference values
were derived from the study by Hinz et al.