S U M M A R Y
Objectives: This study describes the epidemiological and microbiological profile of sepsis during the first
decade of the 21st century in mainland China.
Methods: The sepsis-related mortality data from 2003 and 2007 were retrieved from the China Health
Statistical Yearbook. The microbiology data were retrieved and selected from a literature search of the
China Academic Journal Database between 2001 and 2009. A meta-analysis was performed to synthesize
the available data on the proportion of positive blood cultures in septic patients and the microorganism
distribution.
Results: The sepsis mortality in small and medium-sized cities and rural areas declined obviously over
time. The mortality of the subpopulations aged 1–54 years tended to be lower than the national averages.
In contrast, the sepsis mortality among neonates and the elderly (-
75 years) was obviously higher than
national averages. While the mortality in the elderly declined between 2003 and 2007, the neonate
sepsis mortality increased dramatically, especially among male neonates. The overall positivity of blood
culture were 17.0%, 13.3% and 10.6% among neonatal, pediatric and adult patients with suspected sepsis,
respectively; this proportion tended to decrease over time. Among identified microorganisms, the
proportions of Gram (+) and (–) bacteria were similar (47.2% vs. 44.5%) among adult patients, while Gram
(+) bacteria was predominant among neonatal (77.4%) and pediatric (73.2%) patients and increased in
prevalence over time. The positivity of blood cultures and proportions of microorganisms varied by
geographical region across mainland China. Sepsis with fungus was rare but was more prevalent in adult
sepsis patients (6.4%) than in neonatal patients (0.8%).
Conclusions: The difference in sepsis mortality between urban and rural areas decreased over time.
Males, the elderly, and neonates were found to be high-risk subpopulations. Gram (+) bacteria were
predominant among neonates with sepsis, but the proportion of patients with Gram (+) or Gram (–)
bacteria was similar among adults with sepsis.
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2014 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
This is an open access article under the CC BY-NC-ND license
S U M M A R YObjectives: This study describes the epidemiological and microbiological profile of sepsis during the firstdecade of the 21st century in mainland China.Methods: The sepsis-related mortality data from 2003 and 2007 were retrieved from the China HealthStatistical Yearbook. The microbiology data were retrieved and selected from a literature search of theChina Academic Journal Database between 2001 and 2009. A meta-analysis was performed to synthesizethe available data on the proportion of positive blood cultures in septic patients and the microorganismdistribution.Results: The sepsis mortality in small and medium-sized cities and rural areas declined obviously overtime. The mortality of the subpopulations aged 1–54 years tended to be lower than the national averages.In contrast, the sepsis mortality among neonates and the elderly (-75 years) was obviously higher thannational averages. While the mortality in the elderly declined between 2003 and 2007, the neonatesepsis mortality increased dramatically, especially among male neonates. The overall positivity of bloodculture were 17.0%, 13.3% and 10.6% among neonatal, pediatric and adult patients with suspected sepsis,respectively; this proportion tended to decrease over time. Among identified microorganisms, theproportions of Gram (+) and (–) bacteria were similar (47.2% vs. 44.5%) among adult patients, while Gram(+) bacteria was predominant among neonatal (77.4%) and pediatric (73.2%) patients and increased inprevalence over time. The positivity of blood cultures and proportions of microorganisms varied bygeographical region across mainland China. Sepsis with fungus was rare but was more prevalent in adultsepsis patients (6.4%) than in neonatal patients (0.8%).Conclusions: The difference in sepsis mortality between urban and rural areas decreased over time.Males, the elderly, and neonates were found to be high-risk subpopulations. Gram (+) bacteria werepredominant among neonates with sepsis, but the proportion of patients with Gram (+) or Gram (–)bacteria was similar among adults with sepsis.- 2014 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.This is an open access article under the CC BY-NC-ND license
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