In the population that benefits most from the prophylactic effect of cranberry intake (sexually active women with recurrent UTI), trial results repeatedly show an ∼50% reduction in disease morbidity. From a clinical point of view, this is quite a modest benefit, considering the accompanying burden of long-term daily intake of the compound. Not less significant is the inconvenience associated with the amount of juice required to assure continuous availability and the need to carry a daily supply if twice- or thrice-daily dosing is needed to work, business, or vacation travel. If one considers the understandably high rate of dropouts, the 50% efficacy rate may drop to a remarkably lower effectiveness.