The first important conclusion is the necessity of a pre-drying step to obtain a spouted bed dryer operating in stable conditions. Despite of this behavior, the spouted bed drying was a good alternative for papaya seeds processing, aiming the subsequent oil extraction. The applied conditions (drying time, temperature, and air velocity) contributed to the improvement of papaya seed oil extraction, no affecting the composition of fatty acids. The fatty acids presented in the oil have boiling point far above the temperatures used in this study. Thus, the temperatures used are not sufficient to cause volatilization of the oils.