Johns Hopkins Berman Institute of Bioethics
The Johns Hopkins Berman Institute of Bioethics promotes academic research and educational activities
globally in the field of bioethics and aims at engaging students, trainees, the public and policy-makers in
serious discourse about related issues. The bulletin website offers news, information and resources relating
to bioethics.
Go to: http://bioeth
and promoting international research, the Centre also hosts an annual conference, regular ethics
seminars and a post-graduate professional ethics summer school.
Go to: http://www.surrey.ac.uk/fhms/research/centres/ICE/route of administration, concurrent benzodiazepines, nor ingestion of ETOH were associated with significant decreases in systolic BP or heart rate (P = ns for all comparisons). Decreases in oxygen saturations, however, were significantly larger in ETOH+ patients who received IM olanzapine or IM olanzapine + benzodiazepines. Route of administration, concurrent benzodiazepines, nor ingestion of ETOH was associated with significant decreases in systolic blood pressure or heart rate (p = ns for all comparisons). Decreases in oxygen saturations, however, were significantly larger in ETOH+ patients who received IM olanzapine or IM olanzapine + benzodiazepines. Conclusions: Oral olanzapine was not associated with significant vital sign changes in ED patients. Intramuscular olanzapine also was not associated with vital sign changes in ETOH− patients. In ETOH+ patients, IM olanzapine was associated with significant oxygen desaturations. In ETOH+ ED patients, oral olanzapine (with or without benzodiazepines) or haloperidol may be safer choices. ETOH+ patients may have differential effects with the use of IM SGAs such as olanzapine and should be studied separately in drug trials.
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