Besides, Ca2+ influx was also observed under a confocal laser scanning microscope
in cells after transfection with oligomers–liposomes. It was presumed that not
only OHB but also other OHA can form calcium channels in phospholipid bilayers,
and can be incorporated into plasma membranes and had Ca2+ transport activity.
With successful approval of P4HB as an implant biomaterial by the FDA (http://
www.tepha.com), more PHA-based biomaterials are expected to go into clinical
trials soon. With the diversity of PHA materials, one can expect the PHA to become
a family of bioimplant materials with rich applications.