Abbreviations
NO:
Nitric oxide; PS: Piper sarmentosum; SHR: Spontaneous hypertensive rats;
SBP: Systolic blood pressure; DBP: Diastolic blood pressure; MAP: Mean
arterial pressure; MDA: Malondialdehyde; ROS: Reactive oxygen species;
ED: Endothelial dysfunction; CPK: Creatine phosphokinase; LDH: Lactate
dehydrogenase; S.E.M: Standard error of mean.
Competing interests
The manufacturer of Kadukmy
™
was not involved in the design, funding,
implementation or interpretation of the present study. Therefore the authors
declare that there is no competing interest.
Authors
’
contributions
MMZ performed the study, analysed the data and prepared the manuscript.
ZZ supervised the work, provided the grants for the study, evaluated the data,
corrected the manuscript and coordinated the study. NAMMN supervised the
work, evaluated the data, corrected the manuscript and coordinated the study.
All authors have read and approved the final manuscript.
Acknowledgments
The authors are grateful to Universiti Kebangsaan Malaysia Medical Centre
(FF
–
200
–
2012), Ministry of Higher Education Malaysia (UKM OUP-TKP
–
20
–
97/
2010) for funding this project. Special thanks to Prof. Dr. Srijit Das, Assoc. Prof
Dr. Azarisman Shah Mohd. Shah and Prof.Dr. Pakeer Oothuman for editing
the manuscript, and the technical staffs of Physiology and Anatomy
Department of UKM for their endless suppor