Another important aspect of the measurement of tissue
PCO2 in the sublingual mucosa is that, since it is not part
of the splanchnic area, elevations in PslCO2 may not occur
as fast as in the stomach in progressive shock states.
Hence, it may not serve as a “canary of the body” [65]. In
addition, PslCO2 should always be interpreted in relation
to the arterial PCO2. This latter measurement is subject to
bias and imprecisions related to blood gas sampling and