Risk was elevated regardless of when in the past the heavy consumption had occurred; ORs ranged from 2 to 2.6 for heavy drinking in the past 10, 20, or 30 years (data not shown). When analyses were restricted to the heaviest drinkers, results showed that risk increased with increasing decades of heavy consumption ([21 drinks/week p-trend = 0.02, [35 drinks/week p-trend = 0.01, Table 2).