. Regular
aspirin use after diagnosis was associated with an
impressive lowering of colorectal cancer-specific mortality
among participants in whom primary tumors overexpressed
COX-2 (multivariate HR, 0.39; 95% CI, 0.20-
0.76). This is in contrast to patients with tumours that
had weak or absent cox2 expression where aspirin use
was not associated with lower risk (multivariate HR,
1.22; 95% CI, 0.36-4.18).