Addition of exogenous taurine increase rod
differentiation by about 2.5 fold, an effect seen when P0 tissue is incubated
with both glycine and GABA. Addition of glycine or GABA receptor
agonists (strychnine, bicuculline) resulted in rod production similar to that
seen with controls. Addition of taurine and 1 μM bicuculline resulted in an
induction of rod genesis similar to that of taurine alone. Co-incubation of
taurine and 500 nM strychnine did not significantly increase rod genesis,
suggesting that taurine may act via the glycine receptor in rod formation.