Till 1981 hGH was extracted from cadavers pituitary gland and used for treatment of hGH deficiency cases. The first use of
recombinant human growth hormone for human therapy was in 1981 (Reichert and Paquette 2003). Recombinant human growth hormone(rhGH) is approved for general medical uses for treatment of short stature, poor growth in children, renal failure, and turner syndrome and also as anti ageing drug.