While these preliminary findings suggest that SJW may be an appropriate treatment for depressed pediatric patients, more rigorously conducted research, including placebo controlled studies, clearly are needed before SJW can be routinely recommended for this population
the literature contains numerous double blind studies comparing SJW to a conventional antidepressant, but without utilizing a placebo control. the majority of these studies concluded that SJW was as at least as effective as the conventional product, following short-term (e.g., Szegedi) or long-term (e.g., Anghelescu) use
Other like designed studies have reached similar conclusions regarding SAM-e (e.g., Pancheri139).