Gene Structure
Heisterkamp et al. (1985) determined the structural organization of the BCR gene, which contains 23 exons and occupies a region of about 135 kb on chromosome 22. The first exon contains a unique serine/threonine kinase activity and at least two SH2 binding sites.
Stam et al. (1987) demonstrated that the BCR gene is oriented with its 5-prime end toward the centromere of chromosome 22.
Chissoe et al. (1995) determined that the BCR gene contains 23 BCR exons with putative alternative BCR first and second exons.