Natural derived botanical extracts: A recent trend is to develop newer natural derived extracts for the purpose of skin lightening. A number of plant-derived products are being studied for their depigmenting role in melasma and other pigmentary disorders. In an in vitro study by Hwang et al, 101 plant extracts were studied for inhibitory effect against tyrosinase, L-dopa oxidation and melanin synthesis in B16 melanoma cells. Of these extracts, Broussonetia kazwoki, B. papyrifera, Cornus officinalis, Rhus javanica and Pinus densiflora inhibited tyrosinase and DOPA oxidation in dose-dependent manner. [12] These botanicals have the advantage of being efficacious, and most importantly, they would be the drugs of choice in future being free from any complications.