In english there is a saying that laughter is the best medicine increasingly science is proving that laughter is a valuable part of the body toolbox when we laugh our brains are flooded with chemicals known as endorphins endorphins act as natural painkillers and play a critical role in regulation of mood another benefit of laughing is that we take in a lot of oxygen increased levels of oxygen in the bloodstression have been proven to increase energy providing relief from both fatigue and depression