The S-shaped gram-negative bacterium, colonizes the gastric epithelial surface, and withstands the stomach’s hostile ambience by microaerophilic growth capability and high urease activity. In addition, it produces numerous virulence factors, the most important being urease and catalase . Urease is located on
the cell surface loosely bound into a urease-containing material and hence continually shed into the microenvironment. With regard to therapies for eradication of the disease
produced by this microorganism, colloidal bismuth subcitrate (CBS) (involved in decreased adherence of H. pylori in gastric epithelial cells together with antibiotics, such as amoxycillin, tetracycline, metronidazole, are the drugs currently used against H. pylori.