nfluenza remains a serious disease and a leading cause ofmortality in all regions of the world [1,2]. Influenza viruses arecharacterized by their segmented single-stranded ribonucleic acid(RNA) genome. The virus is surrounded by a lipid containing enve-lope containing two major glycoproteins: HA and neuraminidase(NA). The HA glycoprotein is widely accepted as the critical antigenfor vaccine protection as antibodies against HA exhibit neutralizingactivity [3]. The HA glycoproteins continue to evolve, and there-fore the influenza virus presents a unique challenge to vaccine∗adaptedstrain