The effect of piglet birth weight variation on subsequent weight variations and litter performance in Large White×Landrace sows is not well understood. The objective of the current study was to determine the relationship between within-litter birth weight coefficient of variation (CVB) and performance of piglets at 3 weeks and at weaning. A total of 1836 litter records, collected between January 1998 and September 2010 at the Agricultural Research Council (ARC), Irene, were used. The CVB had a linear relationship with survival at 3 weeks (SURV3) (b=−0.20; P