The effect of the surface chemistry of biomaterials on the protein adsorption process has been a topic of great interest for many years,
and much is known in this field30. Protein adsorption to various
materials has been widely studied and it has been found that factors
such as electrostatic interactions, hydrophobic interactions, and specific
chemical interactions between the protein and the adsorbent play
important roles. Selective adsorption of proteins on various synthetic
adsorbents has been examined under different conditions (such as
solution pH and protein concentration) and for many proteins the
mechanism of selective adsorption has been attributed to electrostatic
interactions12.