Abstract: The objective of this study was to evaluate the toxic impact of wastewater discharge effluent on
aquatic environment. Lead, Zinc, Copper and Cadmium were determined in some tissues of sharp toothed
African Catfish (Clarias garipinus) and Nile tilapia (Oreochromis niloticus) collected from only two sites and
water samples from all six sites. The concentration of heavy metals in water was within the permissible limits
for discharge drain water into River Nile (Egyptian law 48/1982). A significant difference between the four metals
in different / similar tissues of different / similar species (p