The analysis of clinical presentations between two groups of skin lesions and between CVA6 and non-CVA6 infected patients are listed in Tables 1 and 2, respectively. Children with large vesicles were more frequently CVA6-positive (large vesicle group vs. small rash group: 90% vs. 70%, P=0.01) and this type of vesiculobullous lesion more commonly presented on trunks in the large vesicle group (44% vs. 16% P=0.004). Also, children infected with CVA6 had higher chances of developing large vesicles than those without (56% vs. 25%, P=0.02). Pruritus was the most common complaint, and appeared more frequently in the large vesicles group (44%) than in the small rashes group (20%, P=0.01). The incidences of neurological symptoms were similar between two skin lesion groups and between two groups of CVA6 and non-CVA6 infections. None of the patients had complications or sequelae.