We conducted searches using the following bibliographic databases: Ovid MEDLINE, Ovid EMBASE, PubMed and the Cochrane Library for relevant articles published before May 2017. We did not use any date or language restrictions for the bibliographic searches. An example search strategy for one of the databases (Ovid MEDLINE) is included in File S1. We also scanned the reference list of included studies and contacted experts in the field to ask if they were aware of additional published or on-going trials investigating blue-blocking lenses. We searched the PROSPERO database for relevant systematic reviews and searched clinical trials registries (Clinical trials.gov and the ISRCTN registry) for recently completed or on-going trials.