Such post-analyses are both labor-intensive and costly and make
CE-HPLC a less efficient measurement for HbA1c than other
methods from the economic viewpoint.19 Furthermore, if peaks
cannot be separated (due to co-elution) or identified (in the case
of rare Hb variants) an accurate HbA1c value cannot be reported
and the sample has to be retested using an alternative method,
such as by immunoassay. Although CE-HPLC has the ability to
determine which Hb variant is present,21,22 which can lead to
further understanding of the patient’s condition, the primary
aim of HbA1c testing should be to obtain an accurate result.