Treatment: Migraines are a mixed bag for treatment options, but doctor-prescribed triptans (like Imitrex, Zomig, Maxalt) are the most commonly effective pain reliever for people when over the counter solutions like Aspirin don't work. In the middle of a migraine stretching can relieve some symptoms. If all else fails, when you're waiting out the pain, a cold head wrap may provide a little relief.