Objective: To evaluate anti-diabetic effect of Caulerpa lentillifera (C. lentillifera).
Methods: The inhibitory effect of C. lentillifera extract on dipeptidyl peptidase-IV and
α-glucosidase enzyme was measured in a cell free system. Then, interleukin-1β and interferon-γ
induced cell death and insulin secretion were measured in rat insulinoma (RIN) cells by 3-(4,5-
dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and ELISA kit, respectively.
Glucose uptake and glucose transporter expression were measured by fluorometry and western
blotting, using 3T3-L1 adipocytes.