: A database search (1966 to January 2010) was made for (randomized) controlled trials ((R)CTs)
comparing NSAIDs vs acetaminophen in knee and hip OA. Extracted data included baseline demographic/
clinical characteristics, outcomes at follow-up, and characteristics of study design. Heterogeneity was
examined with subgroup analyses by exploring changes in effect size and with I2 of Higgins. Pain
measures were expressed as standardized mean differences.