•
Healthy young males supplemented with vitamin C and E or placebo for 8 weeks.
•
Skeletal muscle biopsies taken pre- and post- acute exercise and endurance training.
•
Vitamin C and E attenuated some (TFAM, SOD) of the skeletal muscle adaptations to training.
•
Skeletal muscle oxidative stress, CS activity, COX IV protein and PGC-1α mRNA were unaffected by supplementation.