UR of bipolar patients presented non-specific disturbances in the connectivity of the frontal-thalamic-basal ganglia network andsensorymotor network that were shared with the other groups.Another study analyzed the amplitude of low-frequency fluctuations (ALFF, measuring regional brain function), and functional connectivity with a seed voxel correlation approach (Lui et al.,2014). It found that UR presented the same type of alteration than bipolar and schizophrenic patients, namely increased connectivity between precentral/postcentral gyrus and the caudate nucleus,bilaterally. Another classical analysis of resting state is through independent component analysis (ICA) and ROI-based connectivity,as in the study from Singh et al. (2014a,b). UR presented differencesonly in the ROI-based connectivity analyses: greater connectivity between the left vlPFC and the left superior parietal lobule.However, they displayed decreased connectivity between the left amygdala and pregenual ACC, sgACC and supplementary motor cortex, and left vlPFC and left caudate. Some of these findings cor-related with age in UR and not in HC, and increased connectivityin vlPFC region was interpreted as compensatory mechanism and a marker of resilience.Probably due to the disparities of methods, these results werenot replicated yet. Overall, the at-rest connectivity between frontal cortex and basal ganglia or limbic/paralimbic regions seems alteredin a non-specific fashion in UR