Once the patient has been stabilized, long-term issues, such as vocational rehabilitation, can be addressed. Medication dosage can be slowly reduced to a maintenance level. In particular, since depot medications tend to accumulate in muscle tissue over time, the dose should be gradually decreased in order to maintain a constant blood level. Attention must be paid to weight gain, possible diabetes, and elevated serum lipids. These are particular concerns for the newer generation of anti-psychotics. Body mass index (BMI) should be continuously monitored throughout treatment. Addressing the problem early can prevent massive increases (50 lbs. or more) and prevent secondary health problems (e.g., hypertension and diabetes mellitus).