Table 1. Previously reported blood curcumin concentrations in humans. Subject Dose (g/Day) Sample Size Plasma Curcumin Level (Means ± SE) Ref.
Healthy volunteers
2 8 6 ± 5 ng/mL [186] 8 6 0.6 μg/mL [189] 12 1 57.6 ng/mL (t = 2 h) [190] Persons with Alzheimer’s Disease 4 30 7.76 ± 3.23 ng/mL [191] Patients with precancerous lesions 8 2 1.77 ± 1.87 mM [192] Patients with chronic inflammatory bowel disease 4 4 2 Pre-intervention 7.3 ± 8.1 ng/mL Post- intervention 3.8 ± 1.3 ng/mL [193] Patients with pancreatic cancer 8 5 134 ± 70 ng/mL [194]
Patients with colorectal cancer 3.6 4
12.7 ± 5.7 nmol/g (normal tissue) 7.7 ± 1.8 nmol/g (malignant colorectal tissue)
[195