(Bakkali et al.,2008) thus denoting the importance of studying its potential toxic- ity. Data from an investigation of acute toxicity indicate safety after its oral and dermal administration, with mild to moderate skin- irritating potential (Opdyke, 1976). Despite the widespread folk use of lemongrass, there are few controlled toxicological studies confirming its efficacy and safety in a long-term treatment, since sub-acute toxicity data are required to verify these two objectives (WHO, 2000). Therefore, the aim of the current study was to inves- tigate the toxicological profile of C. citratus essential oil after acute or repeated oral treatment in male Swiss mice, focusing on bio- chemical and histopathological endpoints, and its genotoxicity by means of the comet assay.