This paper provides a brief introduction to the variety of research areas focusing on spine biomechanics as it pertains to understanding and preventing low back injuries in the workplace. While certainly not a comprehensive review of the literature, some of the earliest,pioneering studies are presented from the following areas: (1) spine tissue testing, (2) estimating spine tissue loading, (3) manual materials handling studies, (4) prolonged or repetitive spine loading, (5) ergonomic assessment tools, (6) sudden/unexpected loading and (7) spine stability. Where possible, some of our own research contributions are integrated into the relevant sections. This paper concludes with a suggestion of some future research directions to continue and enhance the important impact of occupational spine biomechanics.