actinorhodin fermentation was repressed at high concentrations of glucose. In that study the repressive effect of glucose was eliminated by using a fed-batch technique. Marek and Bednarski [13] also reported that catabolite repression influenced lipase synthesis in Rhi-zopus miehei. Lipase production was also affected by pH changes during the fermentation (Fig. 1). Unlike lipolytic activity the biomass concentration increased with increasing glucose concentration