To address the large gap between medical and layman language, these controlled vocabularies (which have low coverage of colloquial adverse effect expressions commonly seen in social media) are then often augmented with a set of colloquial phrases, created through automated scripts (i.e.,through manually crafted patterns, e.g., Yates and Goharian [2013]), manual extraction(e.g., Leaman et al. [2010]), or both (e.g., Benton et al. [2011]).